Basic principles of drug use
Effect of judgment
Drug treatment can be judged from the following aspects: 1, to alleviate the symptoms and reduce the number of deaths. 2, food consumption increased. 3, normal swimming behavior. 4, body-color back to normal.
If antimicrobial treatment failure should be viewed against the following aspects and make medication adjustments: 1, incorrect diagnosis, pathogens are not clear, cause unclear and improper drug selection, 2, although accurate, but due to take chances, delayed the timing, because it’s too serious, most of the fish loss of appetite can not take bait. 3, drug problems, such as lack of effective drugs, or drugs not, or an arithmetical error, or dosing the right way, or using inadequate doses and treatments are not long enough, unable to control infection or cause relapse. 4, no elimination of sources of infection or cause is not eradicated, 5, remove any move sick fish, ponds, removal of stress factors such as illness, an increase in deaths. 6, the body’s defenses lower or disappear, 7, pathogenic bacteria develop resistance. 8, had dual infections. 9, physical and chemical characteristics of seawater and freshwater different, for many drugs (such as copper sulfate, oxytetracycline) efficacy have a great impact, required special attention.
Drug efficacy depends mainly on drug concentration in the blood and its duration, drug concentration in the blood only reaches the minimum inhibitory concentration (the minimum drug concentration required to inhibit the growth of bacteria) or more can play effect. Fish drug concentration in drug formulation, varies with the dose and method of administration, and the species of fish-related. Even the same species, but also because of its size, water temperature, food consumption varies depending on the conditions. In addition, the antibiotic concentrations in the blood are valid, should be based on susceptibility of pathogens. If pathogens are highly sensitive to this drug, the dosage can be less blood levels can be low 1 such as bacteria are only moderately sensitive, in terms of the quantity and blood levels must be high ¥ if the bacteria is not sensitive to drugs, strong resistance, even if the dose is large, nor to inhibit or kill bacteria.