Compatibility of drugs
The incompatibility of drugs is the adverse changes in the use of different drugs in the same prescription. There are 3 kinds of compatibility, that is, the efficacy of the combination of taboo, the physical compatibility of the taboo, the chemical compatibility of the taboo. Physical compatibility is the physical changes that occur between drugs such as adsorption, and the effect of drugs, chemical compatibility, chemical reaction, the combination of different drugs, chemical reaction, and ultimately affect the efficacy or increase the toxicity of drugs.
The phenomenon of drug compatibility is very common, so should pay special attention to, many drugs should be used alone for good. For example: at the same time, Trichlorfon and quicklime can produce poison
More dichlorvos; mixed acidic drugs and basic drugs using possible chemical reactions, the drug failure I of ferrous sulfate can decrease the bactericidal effect of chlorine disinfectant; zeolite and activated carbon has a strong adsorption effect, other drugs should be avoided and their mixed use; the drug tetracycline and not containing iron, calcium, magnesium, aluminum, or feed the same service, because of its complex formation is not easy to absorb the impact absorption, it is not the same service for the latter with sodium bicarbonate, the increase of pH value, can reduce the solubility and affect the absorption of amino sugar; glycosides and cephalosporins combined, can cause acute renal tubule multi point necrosis; cephalosporins and amino sugar glycosides, cephalosporins combination, can increase the renal tubular toxicity.
Dose of antibiotics
Initial antibiotic or antibiotics due to the impure product, not by weight to measure antibiotic intensity, so stipulated that the titer. This particular “unit” is a kind of effective antibiotic composition of the scale. When an antibiotic is made into a pure chemical substance, it can be expressed as a unit of weight. For example, 1 mg penicillin sodium containing 1667 units, or say 1 unit O. 6 micrograms. 1 mg streptomycin alkali containing I OOo unit, namely 1 unit = 1 micrograms; oxytetracycline, erythromycin, kanamycin, neomycin are to its free base 1 mg set for 1 000 units; tetracycline and chlortetracycline element in its hydrochloride salt I mg as 1 000 units I Yi bacteria B to its free base 1 mg set 10 OOo unit (i.e. 1 withdrawal g quite to the 10 units); and business nystatin per 1 mg for 3 been 7oo units.
As mentioned above, the doses of antibiotics is generally to potency unit and a unit of weight not weighing) to represent, for example, oxytetracycline 250 000 units equivalent to 250 mg oxytetracycline soda. Here the 250 mg not weighing, but to a unit of weight. The relationship is
Weight = total number per unit of antibiotic
For example, packaging of oxytetracycline hydrochloride, per capsule containing 250 mg (rather than that of oxytetracycline 250 000 units), such as the purity of the product is 880 units Lu mg, capsulizing actual weighing is computed according to the formula for 294 mg.
Can be seen that the dose of antibiotics have a certain complexity, in the use of the process must be noted.
Compatibility of drugs