Several important concepts
1, drug formulation and preparation
Dosage form is a kind of form that can be processed and modulated, easy to use, save and transport. The dosage form can be divided into liquid, gas, solid, semi solid. Preparation is an individual dosage form of a drug.
2 local effect and absorption
The function of the drug is divided into local and absorptive function. The former is the drug to be absorbed into the blood before the play the role of, such as topical disinfectant on the surface of bacteria killing effect and dipterex of Lernaea ‘”absorption refers to the drug is absorbed into the blood after the play the role of, such as chloramphenicol for furuncle hysteria and ulcer disease. The role of the absorption is extensive, which can be involved in all parts of the body. However, due to the different physical and chemical properties, the distribution of them is not the same as in vivo residence time (or in vivo process). For example, after oral absorption, the part of the body is damaged, and the rest are excreted in the urine, and the drug concentration in urine can be used for sensitive storage. Therefore, different drugs have different indications and effects, should be understood in detail.
3 direct and indirect effects
The direct effect is that the function or form of the function of the object is changed. The indirect effect is the secondary function of the body fluid regulation. The bactericidal or antibacterial effect of the antibacterial drugs is the direct action of the drugs in the aquatic drugs play an indirect role in the drug less.
4 synergistic and antagonistic effects
When two or more drugs used in combination, the role can be strengthened due to compensate each other, can be cancelled or reduced, the former synergistic effect, which is called the twist resistance and dispensing can be using the synergistic effects of other drugs, to strengthen the main drug therapy, and should pay attention to avoid the role of anti Chu. But sometimes in order to offset the side by using bamboo Weiyao other drugs Hangzhou antagonistic effect
With the further study of the mechanism of drug action, the antibacterial drugs can be divided into four categories: 1. 2, stationary or slow acting bactericidal agent, streptomycin, card the kanamycin, gentamicin, 3, fast efficient antibacterial agent, chloramphenicol, erythromycin, tetracycline. 4, slow acting agent — sulfa drugs.
This classification has certain directive significance to the application of antibacterial drugs. The combination of the first and the second drugs can produce a synergistic effect, which is due to the destruction of the integrity of the cell wall, and the second type of drug is readily available in the cell. The third drugs can quickly block the synthesis of proteins, so that the bacteria are still in a state of rest, and therefore, when the first type of combination of the latter may lead to the weakening of the latter activity. Third types and second kinds of combination, often can get the cumulative or synergistic effect, generally does not have an antagonistic phenomenon. While the third category of the first class of antibacterial activity without significant influence, and sometimes can produce cumulative effect, similar drugs can also be used in combination.
With the small amount of disinfectant solution containing chlorine or bromine, iodine can greatly enhance the bactericidal ability. There are some substances have synergistic effect on chlorine containing disinfectant.
Several important concepts