Antibacterial spectrum of antibacterial drugs

Antibacterial spectrum of antibacterial drugs
Antimicrobial spectrum is the range of varieties of bacteria that are sensitive to the drug. Due to the diversity of its physical and chemical properties, the mechanism of its effect on the bacteria is also different. Some are interfering with bacterial cell wall synthesis, some of the damage of bacterial cell membrane, some of which affect the synthesis of bacterial cell proteins or nucleic acids, which lead to drug sensitive bacteria in the range of different drug. So different drugs have different antibacterial spectrum, some drugs are mainly gram positive bacteria (according to Gram stain reaction, can be divided into gram positive bacteria and gram negative bacteria) sensitive, some drugs are sensitive to gram negative bacteria, but also some of the drug gram positive bacteria and gram negative bacteria are sensitive. The two class is called as antibacterial agents, which is referred to as a broad-spectrum antibiotic. The range of different drugs among different drugs is different. The gram negative bacteria were more sensitive to the drug than gram positive bacteria. Fish pathogenic bacteria is gram negative bacteria, so the use of antibiotics in aquaculture is the majority of broad-spectrum antibacterial drugs.
Drug residues and drug withdrawal period
After drugs into the body, to experience from the absorption, distribution, metabolism, and so on a series of processes, and finally discharged from the body. These processes are in need of a certain period of time, and the length of time is mainly related to the physical and chemical properties of drugs and the variety of animals. The drug is completely eliminated from the fish, some only a few days, while others demand for several months. The residual amount is the content of the drug in the body of the fish market. The content may be very low, but when the human body long-term intake of residual drug, the drug is likely to accumulate in the human body, and then the human body to produce toxic and promote the human body to produce drug resistance. To this end, many countries have used the drug for the approval of the withdrawal period. That is to say, if the use of a certain kind of medicine, the need to stop the medicine for a period of time after the sale, so that the fish in the amount of drug residues to reach the maximum allowable concentration of the following. China has this kind of rules (the people’s Republic of China Ministry of agriculture Announcement No. 235), especially the aquatic products export enterprises in this regard problems must be paid attention to, otherwise it will seriously affect the export of aquatic products, the problems in the export of Japanese eel (Anguilla japonica) had precedent. Even more important is the residue of the drug will seriously affect the health of the vast number of consumers in Ankang.

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